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ResourcesQuantum Dots

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Application NotesApplication Notes by ProductFS5LED's and DisplaysNanotechnologyPhotovoltaic / Solar Cells

Photophysical Characterisation of Perovskite Quantum Dots

Perovskite Quantum Dots are a promising new class of light emitters. In this application note a complete photophysical characterisation, comprising of absorption spectra, photoluminescence spectra, photoluminescence lifetime, and quantum yield of two perovskite quantum dots is carried out using the versatile FS5 Spectrofluorometer.
Edinburgh Instruments PublicationsBiology / Life Science

Evidence that the Density of Self Peptide-MHC Ligands Regulates T-Cell Receptor Signaling

Nadia Anikeeva1, Dimitry Gakamsky2, Jørgen Schøller3, Yuri Sykulev1

Noncognate or self peptide-MHC (pMHC) ligands productively interact with T-cell receptor (TCR) and are always in a large access over the cognate pMHC on the surface of antigen presenting cells. We assembled soluble cognate and noncognate pMHC class I (pMHC-I) ligands at designated ratios on various scaffolds into oligomers that mimic pMHC clustering and examined how multivalency and density of the pMHCs in model clusters influences the binding to live CD8 T cells and the kinetics of TCR signaling. Our data demonstrate that the density of self pMHC-I proteins promotes their interaction with CD8 co-receptor, which plays a critical role in recognition of a small number of cognate pMHC-I ligands. This suggests that MHC clustering on live target cells could be utilized as a sensitive mechanism to regulate T cell responsiveness.